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CARBOXYPEPTIDASE B2
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DeCS
Descriptor
English
:
Carboxypeptidase B2
Descriptor
Spanish
:
Carboxipeptidasa B2
Descriptor
Portuguese
:
Carboxipeptidase B2
Synonyms
English
:
Arginine Carboxypeptidase
Thrombin-Activatable Fibrinolysis Inhibitor
Carboxypeptidase B2, Plasma
Carboxypeptidase U
Tree Number:
D08.811.277.656.350.245.125
D08.811.277.656.350.555.225
D08.811.277.656.675.555.225
D08.811.277.656.837.092
Definition
English
:
A carboxypeptidase that removes C-terminal
lysine
or
arginine
from
peptides
and
proteins
.
Carboxypeptidase B2
(CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating
proteins
and
peptides
that are its
substrates
including
FIBRIN
;
KININS
; and
ANAPHYLATOXINS.
History Note
English
:
2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
36082
Unique Identifier:
D025901
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS